It really is hard to ascertain what constitutes an ordinary poisonous or lethal dose. Even so, the lethal oral dose of codeine in an adult is documented to be during the choice of 0.
Youngsters Postmarketing situations of respiratory despair, such as fatalities, have been described with use of promethazine in pediatric individuals. Concomitant administration with other respiratory depressants could raise the risk of respiratory despair.
Promethazine hydrochloride happens as a white to faint yellow, almost odorless, crystalline powder which bit by bit oxidizes and turns blue on prolonged exposure to air.
Stay away from using Promethazine HCl and Codeine Phosphate Oral Solution in adolescents 12 to 18 decades of age who have other chance aspects that will maximize their sensitivity towards the respiratory depressant effects of codeine.
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The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people below six a long time of age. Concomitant administration of promethazine items with other respiratory depressants has an association with respiratory despair, and sometimes death, in pediatric people. The association does circuitously relate to individualized body weight-primarily based dosing, which could if not permit Harmless administration.
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Promethazine is nicely absorbed through the gastrointestinal tract. Clinical results are clear inside of 20 minutes immediately after oral administration and usually past four to 6 hrs, Despite the fact that they may persist as long as twelve hrs.
Phenothiazines are linked to dystonic reactions, especially in pediatric clients who may have an acute health issues affiliated with dehydration. Paradoxical reactions, which includes dystonia, torticollis, tongue protrusion, hyperexcitability, and irregular movements are actually reported in individuals pursuing an individual administration of promethazine. Discontinue Promethazine HCl and Codeine Phosphate Oral Answer if a paradoxical reaction occurs.
Postmarketing situations of respiratory despair, such as fatalities are already claimed with use of promethazine in pediatric patients.
Get health-related enable straight away for those who discover any of the following: sluggish/shallow respiratory, significant drowsiness/problem waking up, confusion.
Postmarketing instances of respiratory depression, together with fatalities happen to be noted with utilization of promethazine in pediatric clients.
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Codeine and promethazine, two of your active elements in Promethazine HCl and Codeine Phosphate Oral Resolution, may possibly produce marked drowsiness and Promethazine codeine syrup impair the psychological and/or physical capabilities demanded for the functionality of potentially hazardous responsibilities for example driving an auto or working equipment. Recommend people to prevent participating in hazardous jobs necessitating psychological alertness and motor coordination soon after ingestion of Promethazine HCl and Codeine Phosphate Oral Solution.